e-mail: Jieru.changer@gmail.com

教育背景:

2017 – 2022 博士

化学与分子生物学院，昆士兰大学，布里斯班，圣卢西亚，昆士兰州，澳大利亚

2016 – 2017 生物技术硕士

化学与分子生物学院，昆士兰大学，布里斯班，圣卢西亚，昆士兰州，澳大利亚

2014 – 2015 生物科学学士（荣誉学士）

皇家海军学院，格林威治大学，帕克罗分校，伦敦，英格兰

期刊文章 :

1. Jieru Yang, Huanmin Kang Yingyi Liu, Yan He*, Wenhu Zhou*, Harnessing Tumor Cell‐Derived Exosomes for Immune Rejection Management in Corneal Transplantation. Advanced Science,12(2),2025, 2409207.

2. Jiangxin Huang, Jieru Yang, Yuanying Yang, Shan Lu, Wenqun Li*, Wenhu Zhou*, Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine. Advanced Science, 2025, 2415227.

3. Jieru Yang, Jiaojiao Zhu, Shan Lu, Wenhu Zhou*, Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering. Journal of Controlled Release, 113664.

4. Shan Lu, Ze Mi, Jieru Yang, Peng Liu, Jinsong Ding, Jieru Yang* Pengfei Rong* and Wenhu Zhou*, Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy. Journal of Nanobiotechnology, 22(1), 2025, 443.

5. Jieru Yang, Jennifer C. Boer, Mattaka Khongkow, Sarunya Phunpee, Zeinab G. Khalil, Sahra Bashiri, Cyril Deceneux et al. "The development of surface-modified liposomes as an intranasal delivery system for group a Streptococcus vaccines." Vaccines 11, no. 2 (2023): 305.https://doi.org/10.3390/vaccines11020305

6. Jieru Yang, Farrhana Firdaus, Armira Azuar, Zeinab G. Khalil, Nirmal Marasini, Robert J. Capon, Waleed M. Hussein, Istvan Toth, and Mariusz Skwarczynski. "Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against Group A Streptococcus." Vaccines 9, no. 5 (2021): 499. https://doi.org/10.3390/vaccines9050499

7. Jieru Yang, Yacheng Luo, Mohini A. Shibu, Istvan Toth, and Mariusz Skwarczynskia. "Cell-penetrating peptides: efficient vectors for vaccine delivery." Current drug delivery 16, no. 5 (2019): 430-443.https://doi.org/10.2174/1567201816666190123120915

8. Dai, Charles C., Jieru Yang, Waleed M. Hussein, Lili Zhao, Xiumin Wang, Zeinab G. Khalil, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Polyethylenimine: An intranasal adjuvant for liposomal peptide-based subunit vaccine against group a streptococcus." ACS Infectious Diseases 6, no. 9 (2020): 2502-2512. https://doi.org/10.1021/acsinfecdis.0c00452

9. Zhao, Lili, Jieru Yang, Ummey Jannatun Nahar, Zeinab G. Khalil, Robert J. Capon, Waleed M. Hussein, Mariusz Skwarczynski, and Istvan Toth. "A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: Lipidation and polyelectrolyte complexes." Bioorganic & Medicinal Chemistry 28, no. 24 (2020): 115823. https://doi.org/10.1016/j.bmc.2020.115823

10. Faruck, Mohammad O., Prashamsa Koirala, Jieru Yang, Michael J. D’Occhio, Mariusz Skwarczynski, and Istvan Toth. "Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate." Pharmaceutics 13, no. 7 (2021): 1081. https://doi.org/10.3390/pharmaceutics13071081

11. Dai, Charles C., Wenbin Huang, Jieru Yang, Waleed M. Hussein, Jingwen Wang, Zeinab G. Khalil, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines." Bioorganic & Medicinal Chemistry Letters 40 (2021): 127920. https://doi.org/10.1016/j.bmcl.2021.127920

12. Dai, Chuankai, Zeinab G. Khalil, Waleed M. Hussein, Jieru Yang, Xiumin Wang, Lili Zhao, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Opsonic activity of conservative versus variable regions of the group a streptococcus M protein." Vaccines 8, no. 2 (2020): 210. https://doi.org/10.3390/vaccines8020210

13. Shalash, Ahmed O., Luke Becker, Jieru Yang, Paul Giacomin, Mark Pearson, Waleed M. Hussein, Alex Loukas, Mariusz Skwarczynski, and Istvan Toth. "Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy." Vaccines 9, no. 9 (2021): 1034. https://doi.org/10.3390/vaccines9091034

14. Shalash, Ahmed O., Luke Becker, Jieru Yang, Paul Giacomin, Mark Pearson, Waleed M. Hussein, Alex Loukas, Istvan Toth, and Mariusz Skwarczynski. "Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection." Journal of Allergy and Clinical Immunology 150, no. 1 (2022): 157-169. https://doi.org/10.1016/j.jaci.2022.02.020

15. Azuar, Armira, Mohini A. Shibu, Nomin Adilbish, Nirmal Marasini, Hong Hung, Jieru Yang, Yacheng Luo et al. "Poly (hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus." Bioconjugate Chemistry 32, no. 11 (2021): 2307-2317.https://doi.org/10.1021/acs.bioconjchem.1c00333

16. Firdaus, Farrhana Z., Stacey Bartlett, Waleed M. Hussein, Lantian Lu, Quentin Wright, Wenbin Huang, Ummey J. Nahar U.J. Jieru Yang et al. "Liposomal Formulations of a Polyleucine–Antigen Conjugate as Therapeutic Vaccines against Cervical Cancer." Pharmaceutics 15, no. 2 (2023): 602.https://doi.org/10.3390/pharmaceutics15020602

基金及资助 :

l 07.2023  EGCG-FA纳米粒递送CRISPR/Cas9基因编辑系统应用开发, 10万，横向

l 11.2022 博士后国际交流计划引进项目，60万，湖南省人力资源和社会保障厅

l 07.2017 Awarded with a Research Higher Degree Scholarship, The University of Queensland，研究高等教育奖学金，昆士兰大学

l 07.2017 Awarded with a UQ Research Training Scholarship, The University of Queensland. UQ研究培训奖学金，昆士兰大学

l 02.2017 Awarded with a Dean’s Commendation for Academic Excellence, The University of Queensland. 成绩卓越奖，昆士兰大学

l 06.2015 Awarded with First-Class Honours, University of Greenwich. 一等荣誉学位，格林威治大学

研究经历:

工作经历 :

学术活动与会议:

1. Yang, J.; Firdaus, F.Z.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, Drug Delivery Australia Virtual Meeting 2020, 23-11-2020. (Poster presentation)

2. Yang, J.; Firdaus, F.Z.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 8th Australasian Vaccines & Immunotherapeutics Development Meeting 2020, 9-10.11.2020. (Speed talk presentation).

3. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 16th Annual Research Student Symposium 2020, The University of Queensland, Brisbane, Australia, 26.11.2020. (Poster Presentation).

4. Yang, J..; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 13th Australian Peptide Conference, Port Douglas, Australia, 08-13.09.2019. (Poster presentation)

5. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 15th Annual SCMB Research Students Symposium, Brisbane, Australia, 28.11.2019. (Poster presentation)

6. Yang, J.;; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, Drug Delivery Australia 2019 Conference, Brisbane, Australia, 18-19.11.2019. (Poster presentation)

7. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Development and delivery of a peptide-based vaccine against group A streptococcus with the help of cell penetrating peptide, The RACI Medicinal Chemistry and Chemical Biology Conference (MCCB), Brisbane, Australia, 18-21.11.2018. (Poster presentation)

实验技能：

· 纳米粒子的合成与表征：熟练掌握制备多种纳米粒子（如微乳液、脂质体、聚合物纳米粒子等）和表征技术（如动态光散射、透射电子显微镜、原子力显微镜等）。

· 细胞培养和分子生物学技术：包括细胞培养、基因克隆、PCR、西方印迹等技术。

· 药物释放研究：能够进行体外和体内药物释放实验，使用各种模型和技术进行药效和毒理学评估。

· 药物动力学和代谢研究：理解并应用药物动力学模型和代谢研究的基本原理。

· 化合物的表征与纯化：使用反相高效液相色谱（RP-HPLC, Shimadzu）和电喷雾电离质谱（ESI-MS）进行化合物的表征与纯化。

· 动物疫苗实验：通过皮下或鼻腔给药途径在小鼠模型上进行免疫学研究。

· 固相肽合成：掌握微波辅助和手工固相肽合成技术（Boc或Fmoc）。

  数据分析技能：

· 统计软件应用：精通SPSS、R或其他统计软件，能够进行高级数据分析和统计检验。

· 图像分析软件：熟练使用ImageJ或其他相关软件进行细胞成像数据的分析。

· 计算机技能：熟练使用Chemdraw、Prism、Endnote等科学研究和文献管理软件。

  软技能：

· 项目管理：能够有效管理科研项目，包括时间管理、资源调配和团队协作。

· 科学写作和沟通：具备撰写科学论文、报告和申请书的能力，以及在学术会议上进行口头和海报展示的经验。

· 团队协作和领导力：在多学科团队中工作的经验，能够领导小组或参与大型项目的合作。